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About Us

Organisers

The University of Cambridge and Cambridge University Hospital NHS Foundation Trust are the joint sponsors of the BEST4 Trials. This means they are responsible for the work.   


The Cancer Prevention Trials Unit at Queen Mary University of London are helping to organise and coordinate the BEST4 Trials. They are the clinicals trials unit running the trials. 

Funders

 Cancer Research UK & the National Institute for Health & Care Research (NIHR) CRUK are the main funders and the NIHR are part funders for the BEST4 Trials.

Researchers

Professor Rebecca Fitzgerald

Professor Rebecca Fitzgerald

Professor Rebecca Fitzgerald

Rebecca is the lead investigator of the BEST4 Trials. Rebecca is Professor of Cancer Prevention at the University of Cambridge and Director of the Early Cancer Institute. Rebecca is a named inventor of the Cytosponge technology and associated laboratory tests and is co-founder of Cyted Ltd. She was awarded an Order of the British Empire (

Rebecca is the lead investigator of the BEST4 Trials. Rebecca is Professor of Cancer Prevention at the University of Cambridge and Director of the Early Cancer Institute. Rebecca is a named inventor of the Cytosponge technology and associated laboratory tests and is co-founder of Cyted Ltd. She was awarded an Order of the British Empire (OBE) in 2022 for services to cancer research. In 2018 she received the Jane Wardle Prevention and Early Diagnosis Prize and in 2021 the Don Listwin Award for Outstanding Contribution to Cancer Early Detection.

Dr Tom Round

Professor Rebecca Fitzgerald

Professor Rebecca Fitzgerald

Tom is the lead researcher and Chief Investigator for the BEST4 Screening Trial. He is a General Practitioner (GP) at Bromley by Bow Health in London and a clinical lead for an e-learning programme for the Royal College of General Practitioners. As a researcher, Tom works in Population Health Sciences at King’s College London. He is also 

Tom is the lead researcher and Chief Investigator for the BEST4 Screening Trial. He is a General Practitioner (GP) at Bromley by Bow Health in London and a clinical lead for an e-learning programme for the Royal College of General Practitioners. As a researcher, Tom works in Population Health Sciences at King’s College London. He is also Associate Editor of the British Journal of General Practice and Royal Marsden Partners primary care research implementation lead. 

Dr Massimiliano Di Pietro

Dr Massimiliano Di Pietro

Dr Massimiliano Di Pietro

Massmiliano is the lead researcher and Chief Investigator for the BEST4 Surveillance Trial. Massimiliano completed his medical and specialty training at the University of Naples.  He then had a postdoctoral role at the Institute of Molecular Cancer Research at the University of Zurich. He joined Cambridge in 2007, first as clinical lectur

Massmiliano is the lead researcher and Chief Investigator for the BEST4 Surveillance Trial. Massimiliano completed his medical and specialty training at the University of Naples.  He then had a postdoctoral role at the Institute of Molecular Cancer Research at the University of Zurich. He joined Cambridge in 2007, first as clinical lecturer and research fellow, and then as Clinician Scientist and Consultant Gastroenterologist.

Professor Peter Sasieni

Dr Massimiliano Di Pietro

Dr Massimiliano Di Pietro

Peter is the joint-lead investigator of the BEST4 Trials. Peter is director of the Cancer Research UK Cancer Prevention Trials Unit, and Vice Director of the NIHR Policy Research Unit on Cancer, Awareness, Screening and Early Diagnosis. Peter read mathematics at Cambridge University and a PhD in biostatistics from the University of Washin

Peter is the joint-lead investigator of the BEST4 Trials. Peter is director of the Cancer Research UK Cancer Prevention Trials Unit, and Vice Director of the NIHR Policy Research Unit on Cancer, Awareness, Screening and Early Diagnosis. Peter read mathematics at Cambridge University and a PhD in biostatistics from the University of Washington. He did his post-doctoral training at the Imperial Cancer Research Fund (later Cancer Research UK (CRUK)) in Jack Cuzick's group.center of everything we do. Our research is designed to improve patients' lives and provide better treatment options for a wide range of medical conditions.

Who has reviewed the trial?

The BEST4 trials have been reviewed and approved by the Health Research Authority (HRA) and the National Research Ethics Service (NRES) East of England – Cambridge East Research Ethics Committee. The trials have also been reviewed and supported by members of the public with heartburn, acid reflux, Barrett’s Oesophagus and oesophageal cancer experience. 


We have worked closely with the BEST4 Patient and Public Involvement Panel in the set up of the BEST4 trials. This panel is made up of six people with reflux who meet the trial criteria. 

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